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Release of basal GnRH was found to be increased during the proestrous and diestrous I in hypothalamic slices of ALC-treated rats, which could mean that ALC stimulates the secretory activity of GnRH-producing hypothalamic neurons

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And I use that analogy when I'm working with patients to really reinforce that it is a chronic relapsing sometimes I don't use disease, people again don't like disease, I'll say condition we can treat it but we don't know exactly how to maintain that healthier body weight without the medication long term in most people