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doi: 10.1016/S0140-6736(23)01200-X 46 JastreboffAMAronneLJAhmadNNWhartonSConneryLAlvesBet al

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Inflammation Obesity triggers chronic inflammation, which contributes to atherosclerosis (narrowing of the arteries)

Nauck, M., Frid, A

Further, it upregulates multiple growth receptors in the body and stimulates the production of fibroblasts, vital to the synthesis of collagen

In cardiovascular system, LC and TMZ are not only influence cardiomyocytes but also may influence other systems working followed by indirectly feedback to cardiomyocytes