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And our comparison of mazdutide vs tirzepatide provides perspective on how other dual-agonist approaches handle the efficacy-tolerability balance

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Both native GLP-1 and GLP-1RA exert multiple actions in the cardiovascular system, including reduction of blood pressure in hypertensive individuals, inhibition of postprandial chylomicron secretion, attenuation of inflammation in the heart and blood vessels, and reduction of ischaemic cardiac injury, but also increases in heart rate (Fig