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You have a smaller appetite, and you dont feel hungry, leading to weight loss

In randomized control trials (RCTs), participants lost an average of 6.6 pounds over 6 months

Tirzepatide to Oral Semaglutide (Rybelsus) Rybelsus (oral semaglutide, 14 mg daily) is approved for type 2 diabetes, not weight management, but it is sometimes used off-label or prescribed as a bridge

Understanding this helps you plan how many vials you need for a complete dosing protocol

Interventions : Wheat dextrin, oral contraceptives: low dose, maltodextrin Primary Outcome Measures: Change in LCL-C measure, change in fasting glucose measure, change in systolic blood pressure, change in diastolic blood pressure, change in BMI, change in Bifidobacteria abundance measured by quantitative polymerase chain reaction (q-PCR), change in single chain fatty acids (SCFA) Time Frame : Baseline and 12 weeks for all outcome measures

But the work is still on you