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Loren Pickart, who noticed that when plasma from young individuals was added to the liver tissue of older individuals, the older tissue would produce proteins more characteristic of younger individuals

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Any diagnostic or therapeutic inference drawn from the group-level GSH reduction therefore remains hypothesis-generating, and would need to be confirmed in larger, independent cohorts using longitudinal designs and ideally more objective indices of disease activity, such as prospective headache diaries or attack-phase measurements

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Iron accumulation and lipid peroxidation constitute the main characteristics of ferroptosis, with a series of genes governing the antioxidant system, iron homeostasis and lipid metabolism orchestrating this cell death modality