In the context of diabetes, chronic hyperglycemia overwhelms the mitochondrial electron transport chain, leading to increased ROS production [176]
Figure 1 Rationale of antioxidant therapy of infertile men: role of oxidative stress In the male genital tract, seminal ROS are produced by sperm, white blood cells, and as by- products during various metabolic processes
While some ROS generation, produced via NADPH-dependent NOX and iNOS, is advantageous and necessary for pathogen clearance, it must be carefully titrated by antioxidant GSH which is itself regulated by NADPH-dependent glutathione reductase
Both are available through GPhC-registered pharmacies following a clinical assessment
doi: 10.1007/s11682-018-0029-4 15 DouaudGLeeSAlfaro-AlmagroFArthoferCWangCYMcCarthyPet al
Once we confirm a deficiency, we'll work with you to figure out what's causing it