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Side effect tolerability varies enormously between individuals

Furthermore, experimental evidence indicates that Epac-mediated inactivation of Src kinase inactivation inhibits the NADPH oxidase (NOX) system, thereby reducing ROS generation (Gianni et al., 2008

These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46

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Embedded microsensors can monitor pH, oxygen, or mechanical strain and detect the first signs of ischemia

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