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DSIP has been studied primarily via intravenous infusion in clinical research (12 mg per session), though subcutaneous injection is also used

A 2023 network meta-analysis published in JAMA found that tirzepatide 15 mg produced the greatest body weight reduction among all approved anti-obesity medications, with an estimated treatment difference of approximately 12 to 15 percentage points over oral semaglutide 14 mg after adjusting for placebo response and trial duration [15]