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Early preclinical studies in experimental diabetes demonstrated toxicities such as anemia, thrombocytopenia, splenomegaly, lymphadenopathy, lung histiocytosis, mortality with multiple organ pathology, gastrointestinal, and central nervous system toxicity
The following factors significantly affect the time it takes for results to appear: Basal metabolic rate: People with low metabolic rates (such as those who sit for long periods or have a tendency towards metabolic syndrome) may need more time to "awaken" their metabolic system
However, the risk can increase slightly when they are combined
Sleep Apnea and Respiratory Improvements Recent clinical trials demonstrate significant improvements in obstructive sleep apnea among GLP-1 users ^14
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