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In Se deficiency, GPx activity decreases, degradation of H2O2 is reduced, thyroid cells are less resistant to oxidative stress, apoptosis and cell death occur ( 3 Se deficiency is one of the risk factors for many thyroid diseases 3.1 Se and Graves disease The main clinical manifestation of Graves disease (GD), also known as toxic diffuse goiter, is thyrotoxicosis caused by excessive production of thyroid hormones

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Consequently, the identification of novel drug combinations that can act synergistically with FINs on ovarian cancer cells represents a promising avenue for addressing this issue

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It is produced by virtually every cell and is essential for protecting DNA, proteins, and cellular structures from oxidative damage