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The recommended approach in clinical settings is a washout period followed by a fresh titration from the starting dose of the new compound
Neurons, specifically, rely primarily on glucose, although they can also use alternative fuels in specific situations (e.g., ketone bodies under prolonged fasting or keto diets [31])
Glutathione S-transferase composition of rat erythrocytes
And, as they took off, docs were eager to see just what else GLP-1s could do
In addition, it needs to be established whether the differential toxicity observed in liver slices can be reproduced using isolated hepatocytes, or in other in vitro models