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The FLOW trial (N=3,533), published in the New England Journal of Medicine in 2024, showed that semaglutide 1.0 mg reduced the composite kidney endpoint by 24% in patients with type 2 diabetes and chronic kidney disease compared to placebo [8], but the trial population was closely monitored
Phase 2 data showed 24.2% weight loss at 48 weeks with no plateau, and Phase 3 TRIUMPH-4 data confirmed continued loss to 28.7% at 68 weeks
Every time you leave the vial out, you are chipping away at the total stability window, even if each individual exposure seems minor
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These agents are likely to vary widely in their affinity and potency at each hormone receptor