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For patients not responding adequately at 12 weeks on a stable maintenance dose, clinicians should verify proper administration technique, assess adherence patterns, and consider whether further dose escalation is appropriate and tolerable before concluding the medication is ineffective

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[5] Additionally, some patients may experience changes in lipid profiles, liver enzymes, or kidney function markers as their metabolic health improves or if side effects such as dehydration from gastrointestinal symptoms develop

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10 Multiple, overlapping effects This illustration summarizes some of the ways GLP-1 drugs work across different body systems