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These findings support their use as a valuable adjunctive obesity management medication (OMMs) in post-bariatric care, though long-term adherence and cost-effectiveness require further investigation

Analysis of time course and dose effect from metformin on body mass index in children and adolescents

And if you are curious about newer options on the horizon, the comparison between semaglutide, tirzepatide, and retatrutide gives you a sense of where the field is heading and what future combinations might look like

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PubMed, Jensterle, Mojca, et al