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Tracking measurements alongside weight helps distinguish between the two since fat loss can continue during water retention periods
Lu Khng dng cho ngi mn cm, king k vi bt k thnh phn no ca sn phm
J Pharmacol Exp Ther 2006;317:11061113
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However, this outcome fell short of the anticipated 25% weight reduction, potentially limiting its competitive edge against Eli Lillys ZEPBOUND, which reported up to 20.9% weight loss in the SURMOUNT-1 trial. In the subsequent REDEFINE 2 trial, which focused on adults with obesity or overweight and type 2 diabetes, CagriSema achieved a 15.7% mean weight loss after 68 weeks, compared to 3.1% with placebo
The Phase 2 trial data confirms this: the 1mg dose group achieved only 8.7% weight loss at 48 weeks, indicating that low doses produce modest effects that accumulate slowly
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