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The downstream release of these three factors, in response to GLP-1R activation, leads to glucose-dependent insulin release

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The British National Formulary (BNF) states: For people with neurological involvement Initially administer hydroxocobalamin 1 mg intramuscularly on alternate days until there is no further improvement, then administer hydroxocobalamin 1 mg intramuscularly every 2 months

A standard program leans on a high, escalating dose to drive those signals hard

Rosner E et al

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