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Pillars 15 , 100186 (2025)
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Retatrutide is currently in Phase 3 clinical trials and is not yet approved by Health Canada or the FDA for obesity treatment
It is unfeasible as a therapy for obesity or diabetes, as patients would essentially need to be tethered to a continuous intravenous infusion
in patients with T2DM (38) found that continuous GLP-1 administration via a subcutaneous pump to raise serum GLP-1 levels from a mean of 9.7 pM at baseline to 282 pM over 6 weeks significantly reduced plasma glucose concentrations, improved glycated hemoglobin, and enhanced insulin sensitivity and -cell function compared to placebo, with no significant limiting side effects reported
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