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J Endocrinol (2008) 198(2):36774.10.1677/JOE-08-0113 108 WeigertCHennigeAMLehmannRBrodbeckKBaumgartnerFSchableMet alDirect cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

Use it regularly but gently

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Therefore, structured interventions incorporating dietary guidance, targeted training, and accountability measures are not merely beneficialthey are essential

During this time, investigators assessed insulin dosing at mealtimes and provided carbohydrate counting education or advised participants to use a simplified meal bolus strategy (ex: small, medium and large, fixed dose, or correction-only)

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