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Conversely, protective factors include long-term stable therapy (greater than 3 months) due to tachyphylaxis effects, asymptomatic patients without gastrointestinal complaints, properly timed medication cessation when indicated, and absence of additional gastroparesis risk factors [13]

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In response to nutrients, enteroendocrine L-cells and K-cells produce and release the incretin hormones including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), respectively [2]