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Buse JB, Vilsboll T, Thurman J, et al

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Constipation rates vary by formulation and dose, with approximately 5-15% of patients on Ozempic and 11-24% of patients on Wegovy reporting constipation

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For weight loss peptides, the relationship is inverse: semaglutide and tirzepatide use fixed-dose titration regardless of starting weight

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It is for this reason that the latter is not routinely available on the NHS and hydroxocobalamin is the preferred treatment

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Deanfield J, Verma S, Scirica BM, et al

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