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The TRANSCEND-T2D-1 trial reported in March 2026 found 16.8% weight loss and a 2.0% reduction in HbA1c (a marker of average blood sugar) at the 12 mg dose over 40 weeks in adults living with type 2 diabetes
Treat it like skincare: your results build over time
The total time semaglutide remains active in your body does not change significantly with split dosing
Each 1% increase in A1C represents roughly a 29 mg/dL increase in average blood sugar
Experts emphasize that these drugs should complement not replace foundational lifestyle habits like nutrition, exercise, sleep, and stress management
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