Since ascorbate is a hydrophilic chemical, it reacts at the lipid/water interface to shield cell membranes from oxidative stress and free radicals in the cytosol [167,168,169,170]
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Inadequate sleep raises ghrelin (hunger hormone), reduces leptin (satiety hormone), impairs glucose metabolism, and increases cortisol four mechanisms that directly counteract GLP-1 therapy
It is best to avoid it entirely during these periods
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Pyridoxine needs are elevated during pregnancy