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CPT1C is localized in the CNS, is a neuron-specific isoform, is expressed in the ER rather than the mitochondria, and has carnitine palmitoyltransferase activity [188]

A pooled analysis showed that people who lost at least 5% of their original body weight within the first four months on Contrave lost an average of 12% by 56 weeks

+ - If the medication time does not match the individual's internal biological clock, theoretically it may lead to a "desynchronization" of the rhythm, which may worsen sleep or emotional disorders