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At least 20 biological replicates (DTCs) were examined

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Of the surveyed propolis ointment group, 81.8% judged their treatment to be very effective compared to 60% of the placebo group finding the ointment hardly effective. 8 Utilizing propolis in conjunction with acyclovir has been shown to synergistically suppress HSV-1/-2 recurrence over acyclovir alone

This means that even twice-daily dosing leaves long windows without measurable peptide

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Noticeable changes typically appear after 6-8 weeks of consistent treatment, although some may observe improvement earlier