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Complex chronic illnesses frequently disrupt the endocrine system, leading to secondary hypothyroidism, sluggish metabolic function, and severe temperature dysregulation

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The GLP-1RA cohort compared with the SGLT2 cohort included more women, more Black people, had higher SDOHs and prevalence of thyroid disorders, kidney disease, and prior prescriptions of opioids, diuretics, antihistamines, and antidepressants

Its usually the result of multiple small disruptions over the time

Our proteomic analysis focused on just one brain region, limiting our ability to understand broader molecular changes across reward circuits