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For some people, the benefits of these medications do not outweigh the risks, as with any other pharmacologic intervention (e.g., adults who have previously had medullary thyroid cancer, in which they are contraindicated)

Bibcode:1964Natur.203.1068H

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PubMed, Florez, Jose C., et al

To be metabolized, fatty acids have to reach the inner compartment (i.e., the matrix) of mitochondria, which is where beta-oxidation takes place

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