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Novo Nordisk has since developed a higher-dose 7.2 mg formulation that pushes results closer to 20.7% in the STEP UP trial, but this version is still making its way through regulatory channels
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Ideal candidates include adults with BMI 27 with weight-related comorbidities or BMI 30, without contraindications, capable of adhering to injection schedules, and able to integrate lifestyle changes
A recently published study (ESSENCE Trial) in the New England Journal of Medicine looked at the effects of once weekly semaglutide 2.4mg versus placebo in patients with biopsy-confirmed MASH
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Without that foundation, even tirzepatide remarkable efficacy will be compromised by poor dietary choices, sedentary behavior, or chronic sleep deprivation
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