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Although SCFAs can cross the BBB, serotonin and GABA generally do not, unless barrier integrity is compromised, as seen in stress and depression models (Margolis et al., 2021)

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The importance of DNL in NAFLD is further supported by studies, showing that in obese patients with NAFLD, approximately 26% of hepatic triglycerides were derived from DNL and that these patients were unable to regulate DNL when transitioning from fasting to fed state [40]