Metabolic syndrome in a sub-Saharan African setting: central obesity may be the key determinant
By restoring mitochondrial function at the cellular level, SS-31 addresses one of the upstream causes of nerve damage that other peptides do not directly target
69 In addition to its use in diabetes management, GLP-1RA has also shown potential in other areas of research
Singh N, Stewart RAH, Benatar JR
Liraglutide: short-lived effect on gastric emptying long lasting effects on body weight
This is analogous to the evidence pathway followed for liraglutide (LEADER trial, NEJM 2016) and semaglutide (SUSTAIN-6 trial, NEJM 2016), which established cardiovascular benefit for those agents only after large, long-term CVOTs reported [6] The heart rate increase warrants ongoing surveillance, particularly in patients with pre-existing cardiac conditions Phase 3 trials are currently underway (see ClinicalTrials.gov and the EU Clinical Trials Information System, CTIS, for registered studies)