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Appl Microbiol Biot 36(4):538540

The combination of GLP-1RA and SGLT-2i was found to produce additive cardiovascular benefits compared to either treatment with one agent alone [33]

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Orforglipron is an investigational oral, non-peptide (small-molecule) GLP-1 receptor agonist developed by Eli Lilly, originating from a Chugai discovery program

The mechanism of action is mediated by its binding to the GLP-1 receptor on -cells of the pancreas to stimulate insulin secretion, slow gastric emptying, and reduce postprandial glucagon secretion in a glucose-dependent fashion

In a rodent model, repetitive dosing of ipamorelin increased fecal pellet output, food intake, and body weight gain 5