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Small molecule inhibitors of nicotinamide N-methyltransferase (NNMT). Journal of Medicinal Chemistry, 59(19), 90399056
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Bdescu GM, Flfan M, Sandu RE, Surugiu R, Ciobanu O, Popa-Wagner A
Useful target-engagement readouts may include reduced 1-methylnicotinamide formation, changes in nicotinamide-related metabolites, and confirmation that the selected cellular or tissue model expresses NNMT at a level relevant to the experimental question
