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The others are cysteine-based superfamilies, including the ubiquitin-specific proteases (USPs), Ub C-terminal hydrolases (UCHs), Machado-Joseph disease domain proteases (MJDs), motif interacting with Ub containing novel DUB family (MINDYs), ovarian tumour proteases (OTUs) and the zinc-finger and UFSP domain protein (ZUFSP) ( These DUBs can play various biological roles, thanks to their unique structural characteristics

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