Furthermore, the tumor suppressor p53 serves as a critical node connecting these pathways as it can promote ferroptosis via SLC7A11 repression while simultaneously regulating apoptotic gene expression (144)
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Because abnormal epigenetic marks disrupt the expression of specific tumor suppressor genes in cancer cells, compounds that re-induce their transcription, like those inhibiting HDACs, can potentially promote differentiation and apoptosis in transformed (precancerous) cells (37)