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An analysis of social media posts mentioning semaglutide and other GLP-1s found that some users said their sleep worsened on semaglutide while others said it improved

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In the STEP 1 trial published in Diabetes, Obesity, and Metabolism , participants who paired weekly semaglutide for weight loss with a structured lifestyle intervention regained an average of two-thirds of the weight theyd lost within one year after stopping both

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as well as HPA-axis 172,173 which could affect stress and SNS