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A separate line of research concerns vascular biology
A randomized Phase II clinical trial confirmed that the triple therapy combination of an anti-PD-1 antibody (Sintilimab), an HDAC inhibitor (Citarinostat), and an anti-VEGF antibody (Bevacizumab) demonstrated significant clinical efficacy in colorectal cancer
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[PMID: 6138744] PubMed record related to this compound for laboratory literature review
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En un estudio intravenoso pequeo (n=6) se report buena tolerancia sin efectos adversos observados (PMID 6895513), pero esto no constituye un perfil de seguridad completo y no hay datos detallados de toxicidad ni contraindicaciones
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