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Because chronic inflammation is strongly associated with metabolic dysfunction, this mechanism has generated interest among researchers studying metabolic disease

High amounts of physical or emotional stress can cause muscle tension, leading to spasms to occur throughout the body

For persistent or atypical cramps, evaluate for metabolic (e.g., renal failure), endocrine (thyroid disorders), medicine-induced, and neuromuscular causes (Garrison et al., 2020)

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Failure to receive prompt treatment may result in sequelae such as dystonia, quadriplegia, and mental retardation, and even death