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The patient situation where surgery becomes superior: BMI 35 (or BMI 30 with Type 2 diabetes or other conditions) Already using Mounjaro or Zepbound Suffering from high OOP cost Worried about decades of injections ahead Desire to resolve problem, not manage forever In such cases, patients find themselves eligible for BMI for bariatric surgery e which costs less than 2-3 years of tirzepatide while providing better results

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Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials