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While meningococcal interactions on the surface of epithelial and endothelial cells have been intensively investigated, leading to the identification of key determinants of virulence of this bacterium, relatively little is known about the crossing of the nasopharyngeal epithelial barrier (NEB), the BBB, and BCSFB by the meningococcus

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These dUTPase proteins, along with other viral dUTPases such as HSV-1 and HHV-6, are thought to promote cellular damage and promote autoimmune features, as well as promoting mitochondrial fusion and decreasing energy production (127)

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SLC22A4 gene (23)

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