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The reason for the lower price: Eli Lilly is cutting out the middlemen (such as telehealth companies and concierge docs), who add hefty markups, and will be selling the drug in vials, rather than the costlier, trickier-to-manufacture preloaded pen form (also known as an autoinjector)
Reconstituted solution is more vulnerable because hydrolysis, contamination risk, temperature swings, and repeated vial access all become more important
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This redundancy raises theoretical concerns about excessive suppression of hunger, rapid weight loss, and potential cardiovascular strainespecially in patients with underlying hypertension or cardiac conditions
