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After 4 weeks, the dose is increased to 0.5 mg once weekly

However, successful clinical translation will require addressing persistent challenges, including biosafety, biodistribution, tumor heterogeneity, and large-scale manufacturability

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Two oral GLP-1s have now received FDA approval: Novo Nordisks WEGOVY pill (December 2025) and Eli Lillys FOUNDAYO (April 2026)

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