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Watch for: Whether dysesthesia incidence differs between diabetes and general obesity populations Time-to-onset patterns across trials Resolution rates in patients who reduced or stopped treatment Impact on discontinuation in non-osteoarthritis populations Subgroup analyses identifying who develops dysesthesia most Conclusion Dysesthesia affecting 12.520.9% of patients at retatrutide's highest dose depending on population is not a minor detail
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Based on these results, we hypothesized that GLP-1R in the TNC mediates microglial activation via the PI3K/Akt pathway and suppresses the central sensitization of CM
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