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When this conversion is impaired due to reduced methylfolate, homocysteine accumulates in the blood, causing inflammation and oxidative stress in blood vessels

Data availability All data used for this paper are publicly available and are provided in the main text and Supplementary Information

To date, tens of thousands of research participants have received GLP-1RAs in RCTs investigating efficacy for improving glycemic control, body weight, and cardiovascular outcomes

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Delton Family Distinguished Professor in Organic Chemistry, and Joshua Munger, professor in the Department of Biochemistry and Biophysics and an expert in cancer cell metabolismare exploring ways to refine potential drugs that could inhibit this process and improve outcomes for patients