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Maintain minimum dose spacing: 48 hours for semaglutide and 72 hours for tirzepatide

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6 Assessment of MK-801 as a half-life extender of gut peptide hormones

The Phase 2 trial (Jastreboff et al., NEJM 2023) tested doses from 0.5mg to 12mg

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Testing levels and adjusting supplementation accordingly produces better outcomes than standard dosing