The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG
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Ultimately, the integrity of any scientific study depends on controlling variables
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Dolotov and colleagues showed it shapes cognition by tuning several neurotransmitter systems at once dopamine, serotonin, and noradrenaline among them