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Meanwhile, LONP1 overexpression ameliorates cholesterol- and palmitate-induced mitochondrial dysfunction and insulin resistance
While most patients tolerate the treatment well, mild side effects such as headaches or minor discomfort can occasionally occur
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To approach the efficacy of BS, dual and triple agonists combining GLP-1 with other entero-pancreatic hormones with complementary actions, including glucose-dependent insulinotropic polypeptide (GIP), glucagon (GCG) and amylin are currently under development [15]
These medications complement lifestyle modifications by targeting hunger and fullness signals, aiding in effective weight management
However, most mechanistic evidence derives from experimental and ex vivo studies, whereas human data remain largely associative
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