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Collectively, these studies imply mutant ALS proteins produce inflammatory cytokines, disturb redox homeostasis, and increase neuroinflammation and toxicity

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Figure 1 2.1 The core enzymatic triad: BCAT4, MAM1, and CYP79F1 The commitment of methionine to aliphatic glucosinolate synthesis is driven by three pivotal enzymes, each executing a distinct and non-redundant step in the construction of the glucoraphanin backbone ( Figure 2 )