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Predisease individuals were defined as having RA-specific autoimmunity (ACPA assessed by testing positive for anticyclic citrullinated peptide 2 IgG autoantibody reactivity) but no past or present evidence of joint swelling according to phases C and D of the RA-at risk definition 45

Matsushita M, Freigang S, Schneider C, Conrad M, Bornkamm GW, Kopf M

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Ongoing studies continue to examine cellular communication, angiogenic signaling, extracellular matrix remodeling, connective tissue physiology, and tissue homeostasis