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Eckert KG et al

Byers, P

Catalase, a tetrameric ferriheme oxidoreductase, facilitates the breakdown of hydrogen peroxide into water and oxygen (259) Glutathione peroxidase, a selenium-dependent oxidoreductase, utilises hydrogen peroxide or organic hydroperoxides as substrates, with reduced glutathione (GSH) acting as the electron donor (260) The reactions include: H 2 O 2 + 2GSH 2H 2 O + GSSG and ROOH + 2GSH ROH + H 2 O + GSSG (261, 262)

Dec 2010;30(12):5145-5151

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Thus, cancer cells have the ability to immunoedit by down regulating or changing key molecules in the IFN- signalling cascade, which ultimately leads to immune evasion