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[3] [255] Evidence from studies that measured the effect of serum DBH concentrations on 4-hydroxyamphetamine metabolism in humans suggests that a different enzyme may mediate the conversion of 4-hydroxyamphetamine to 4-hydroxynorephedrine

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Inhibiting NNMT with 5-amino-1MQ reverses this: NAD+ levels rise, mitochondrial respiration increases, and white adipose tissue (fat storage) shifts toward thermogenesis