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That is why it can be swallowed at all, and why it behaves like a small-molecule drug: real oral absorption, first-pass liver metabolism, a huge volume of distribution (39 L/kg in mice), and off-target enzyme binding

It may take several weks of treatment to notice improvement of condition

Vitamin D deficiency has now been linked to breast cancer, colon cancer, prostate cancer, heart disease, depression, weight gain, and other maladies

For instance, rotating injection sites can minimize local reactions, while staying well-hydrated can reduce headaches and dizziness

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